Cutaneous mosaicisms: concepts, patterns and classifications*
نویسندگان
چکیده
A mosaic is an organism composed of two or more genetically distinct cell populations derived from a genetically homogeneous zygote. Cutaneous mosaicisms are the clinical expressions of these disorders. The main event which allows the existence of mosaicism is a genetic mutation, either structural or functional. Cutaneous mosaicisms usually manifest by specific patterns on the skin and the archetypic pattern is the system of Blaschko lines, but others include checkerboard, phylloid, large patches without midline separation and lateralization. Since 1901, when Blaschko lines were first described, the study of mosasicism has helped to elucidate the behavior of numerous genetic diseases, generating therapeutic perspectives for these pathologies, including the promising gene therapy.
منابع مشابه
Classification: More than Just Branching Patterns of Evolution
The past 35 years in biological systematics have been a time of remarkable philosophical and methodological developments. For nearly a century after Darwin's Origin of Species, systematists worked to understand the diversity of nature based on evolutionary relationships. Numerous concepts were presented and elaborated upon, such as homology, parallelism, divergence, primitiveness and advancedne...
متن کاملClinical patterns of pigmentary mosaicism - our experience
Pigmentary mosaicisms are nevoid diseases characterized by the presence on the skin of hyperor hypopigmented macules with particular clinical patterns. Occasionally they show association with extracutaneous defects that may alter the normal development of the affected person. We present a compilation of all the cases of pigmentary mosaicism evaluated at our Department in the past decade (Dermat...
متن کاملCutaneous adverse drug reactions: A one year prospective study
Background: Adverse cutaneous drug reactions are unwarranted effects of modern medicine. These unfortunate events can assume any morphology from simple exanthem to full blown toxic epidermal necrolysis (TEN), and can simulate and mimic many diseases. Sometimes it is difficult to recognize the cause, but they may be due to polypharmacy or self-administration of medications. The analytical data f...
متن کاملGod sides with us: Reconstructing domain boundaries of causal concepts in Tonga
Research in cognitive and developmental psychology scrutinizes causal concepts predominantly from a domainspecific perspective. In particular, natural and supernatural concepts are frequently subordinated to incompatible and mutually exclusive domains. The profound ethnographic knowledge of cultural anthropology and recent psychological work suggest, however, that causal concepts can easily inc...
متن کاملIntraspecific Variation in Leishmania major Isolated from Different Forms of Zoonotic Cutaneous Leishmaniasis
Background: Zoonotic cutaneous leishmaniasis (ZCL) is a polymorphic disease which may show various clinical manifestations. Although genetic variability of the parasite is suggested to be one of the factors influencing clinical manifestations in leishmaniasis, no data exist regarding genetic polymorphism of Leishmania major. Therefore, determination of genetic variation within the species of L....
متن کامل